01-04-2009, 04:20 AM
ok those with ans CC..its party time!!
With the constellation of different symptoms, Raynaud's phenomenon, arthralgias, heliotrope rash and pleuritic friction rub on exam, this patient is most likely is suffering from Mixed Connective Tissue Disease. This disease presents with various symptoms that are typical of other connective tissues diseases and is seen with a positive anti-U1-RNP antibody (option C).
Anti-Jo (option A) is typically seen in polymyositis which presents with proximal muscle weakness and heliotrope rash (in dermatomyositis), but not with Raynaud's.
Anti-Scl-70 (option B) and Anti-centromere (option D) are seen in diffuse and CREST forms of scleroderma, respectively. However, the rash described is not typical.
Anti-ds DNA (option E) is associated with SLE which typically presents with a malar (butterfly) rash not the heliotrope rash described in the stem.
With the constellation of different symptoms, Raynaud's phenomenon, arthralgias, heliotrope rash and pleuritic friction rub on exam, this patient is most likely is suffering from Mixed Connective Tissue Disease. This disease presents with various symptoms that are typical of other connective tissues diseases and is seen with a positive anti-U1-RNP antibody (option C).
Anti-Jo (option A) is typically seen in polymyositis which presents with proximal muscle weakness and heliotrope rash (in dermatomyositis), but not with Raynaud's.
Anti-Scl-70 (option B) and Anti-centromere (option D) are seen in diffuse and CREST forms of scleroderma, respectively. However, the rash described is not typical.
Anti-ds DNA (option E) is associated with SLE which typically presents with a malar (butterfly) rash not the heliotrope rash described in the stem.