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The fact that type IV osteogenesis imperfecta can be caused by defects
on COLIA 1 and COLIA 2 is an example of
a. Gonadal mosaicism
b. Genetic heterogeneity
c. Allelic heterogeneity
d. Polymorphism
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The answer is b. Genetic heterogeneity is
defined as a situation in which mutations of different genes produce similar
or identical phenotypes. Gonadal mosaicism refers to mutation affecting
some of the germ cells (sperm or eggs). Allelic heterogeneity refers to the
state in which multiple alleles at a single locus can produce a disease phenotype
or phenotypes.
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The answer is b. Genetic heterogeneity is
defined as a situation in which mutations of different genes produce similar
or identical phenotypes. Gonadal mosaicism refers to mutation affecting
some of the germ cells (sperm or eggs). Allelic heterogeneity refers to the
state in which multiple alleles at a single locus can produce a disease phenotype
or phenotypes.