01-16-2008, 07:39 AM
methotrexate- inhibits dihydrofolate reductase
mercaptopurine and thioguanine (both purine analogues that inhibit purine synthesis),
azacytidine (limits pyrimidine synthesis by inhibiting orotidylate decarboxylase),
hydroxyurea (inhibits formation of deoxyribonucleotides from ribonucleotides),
5-fluorouracil (inhibits thymidylate synthase) and
cytarabine (AKA cytosine arabinoside, which inhibits DNA
polymerase).
any more??
mercaptopurine and thioguanine (both purine analogues that inhibit purine synthesis),
azacytidine (limits pyrimidine synthesis by inhibiting orotidylate decarboxylase),
hydroxyurea (inhibits formation of deoxyribonucleotides from ribonucleotides),
5-fluorouracil (inhibits thymidylate synthase) and
cytarabine (AKA cytosine arabinoside, which inhibits DNA
polymerase).
any more??